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陈晓霖主任医师

科室: 神经外科

擅长:复合手术治疗复杂脑血管病,脑动静脉畸形外科治疗,动脉瘤手术治疗,烟雾病颅内外血管搭桥,颈动脉狭窄内膜剥脱,海绵状血管瘤切除以及颅内肿瘤切除等

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个人简介 社会任职 主研方向 获奖情况 学术论著

陈晓霖   北京天坛医院神经外科主任医师, 副教授,硕士生导师。北京医学会神经外科学分会脑血管外科学组秘书。医学博士,美国留学回国人员 。

从事神经外科工作18年,长期在天坛医院神经外科脑血管病团队工作,临床主要研究方向为复合手术治疗复杂脑血管病,脑动静脉畸形外科治疗,动脉瘤手术治疗,烟雾病颅内外血管搭桥,颈动脉狭窄内膜剥脱,海绵状血管瘤切除以及颅内肿瘤切除等。

获得奖励:2019年度北京市科学技术进步二等奖,排名第六

教育经历:

(1)2008年9月~2011年7月,首都医科大学附属北京天坛医院,医学博士,导师:赵元立教授

(2)2005年9月~2008年7月,首都医科大学附属北京天坛医院,医学硕士,导师:赵继宗院士

(3)1998年9月~2003年7月,首都医科大学临床医疗系,医学学士

科研与学术工作经历:

(1)2021年至今,首都医科大学附属北京天坛医院神经外科,主任医师

(2)2019年6月至今,首都医科大学附属北京天坛医院神经外科,副教授,硕士生导师。

(3)2015年12月~2020年12月,首都医科大学附属北京天坛医院神经外科国家神经系统疾病临床医学研究中心,副主任医师

(4)2015年12月28日~2016年12月27日 美国加州大学旧金山分校(UCSF),临床科研访问学者

(5)2013年1月至今,首都医科大学附属北京天坛医院神经外科国家神经系统疾病临床医学研究中心,主治医师

(6)2003年9月~2012年12月,首都医科大学附属北京天坛医院神经外科国家神经系统疾病临床医学研究中心,住院医师

(7)2008年9月~2011年7月,首都医科大学附属北京天坛医院,博士研究生 

a)2009年9月~2010年11月,美国纽约州罗彻斯特大学(University of Rochester.NY),转化神经医学中心,访问学者

b)2010年11月~2010年12月,美国亚利桑那大学,凤凰城神经外科中心BNI,访问学者

主持或参加科研项目(课题)及人才计划项目情况:

1)科技部“主动健康和老龄化科技应对”专项,2020YFC2004701;老年人多病共患临床数据的采集与存储标准研究;2020/07-2023/06, 32万,在研,合作单位负责人

2)国家自然科科学基金青年项目,81801140,基于QSM定量成像分析铁沉积影响脑血管畸形出血及癫痫发生风险的机制研究,2019/01-2021/12,21万元,在研,参加

3)国自然青年基金 81500995,血流动力学调控人脑动静脉畸形内皮细胞表达酪氨酸激酶家族ephrinB2-EPHB4的机制研究,2016/01-2018/12,17.5万元,结题, 项目主持人

4)美国 NIH R01 合作课题,NS034949-18,Predictors of Spontaneous Cerebral AVM Hemorrhage,2013/07-2018 /06, 20 万元, 结题, 中方参与者

5)国家自然科学基金面上项目,81571110,巨噬细胞介导炎症反应诱发脑动静脉畸形破裂出血机制研究,2016/01-2019/12,57万元,结题,项目参与者

6)国家自然科学基金面上项目,81271313,酪氨酸激酶家族配体 EphrinB2调控脑动静脉畸形血管生成的机制研究,2013-2016, 65万元, 结题,第一参与人 

发表SCI文章(第一作者或通讯作者)

1.Ma L, Zhang S, Li Z, Wu CX, Wang Z, Zhan L, Hao Q, Wang H, Ye X, Chen X*, Liu YO, Wang S, Zhao YL*. Morbidity After Symptomatic Hemorrhage of Cerebral Cavernous Malformation: A Nomogram Approach to Risk Assessment. Stroke2020 Oct;51(10):2997-3006. (IF=7.19)

2.Chen Y, Ma L, Yang S, Burkhardt JK, Lu J, Ye X, Jiang W, Ren Z, Wang R, Chen X*, Zhao Y. Quantitative Angiographic Hemodynamic Evaluation After Revascularization Surgery for Moyamoya Disease.Transl Stroke Res. 2020 Feb 13(IF=5.78)

3.Chen Y, Ma L,Chen X*. Responses to "Letter to Quantitative Angiographic Hemodynamic Evaluation After Revascularization Surgery for Moyamoya Disease" Transl Stroke Res. 2020 Apr 17.  doi: 10.1007/s12975-020-00812-1 (IF=5.78)

4.Chen, Y., R. Li, L. Ma, Y. Zhao, T. Yu, H. Wang, X. Ye, R. Wang, X. Chen*, and Y. Zhao*. "Single-Stage Combined Embolization and Resection for Spetzler-Martin Grade Iii/Iv/V Arteriovenous Malformations: A Single-Center Experience and Literature Review." Front Neurol 11 (2020): 570198 (IF=2.89)

5.Yan C, Wang J, Yang Y, Ma W*, Chen X*. Molecular biomarker-guided anti-angiogenic targeted therapy for malignant glioma. Journal of cellular and molecular medicine. 2019;23(8):4876-4882. (IF=4.65)

6.Yan C, Zhu S, Sun H, Jenn WL, Zhang X, Xu Z, Kong X, Chen X*, Neuronavigator-guided ventriculoscopic approach for symptomatic xanthogranuloma of the choroid plexus in the lateral ventricle. Medicine 2019, 98(16):e14718. (IF=1.87)

7.Burkhardt JK#, Chen X#, Winkler EA, Weiss M, Yue JK, Cooke DL, Kim H, Lawton MT. Early Hemodynamic Changes Based on Initial Color-Coding Angiography as a Predictor for Developing Subsequent Symptomatic Vasospasm After Aneurysmal Subarachnoid Hemorrhage. World Neurosurg 2018;109:e363-e373. (IF=1.72)

8.Xiaolin Chen#, Danial Cooke, David Saloner, Jeffrey Nelson, Hua Su,, Michael T. Lawton Christopher Hess ,Tarik Tihan, Yuanli Zhao, Helen Kim, "Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages." Stroke 2017;48:2881-2884. (IF=6.03)

9.Burkhardt JK#, Chen X#, Winkler EA, Cooke DL, Kim H, Lawton MT. Delayed Venous Drainage in Ruptured Arteriovenous Malformations Based on Quantitative Color-coded Digital Subtraction Angiography. World Neurosurg 2017;104:619-627.(co-first author,IF=1.92)

10.Chen XL#, Chen Y#, Ma L#, Burkhardt JK, Wardell T, Wang C, Guo G, Wang S, Zhao YL. Translucent Appearance of Middle Cerebral Artery Bifurcation Aneurysms Is Risk Factor for Intraoperative Aneurysm Rupture During Clipping. World Neurosurg 2017;101:149-154. (IF=1.92)

11.Ren, Z#., Chen, X#., Yang, J#., Kress, B., Tong, J., Liu H., Takano T., Zhao, Y. and Nedergaard, M.; Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter. Neuroscience. 2013, 241:89-99. (IF=3.38)

12.Takano, T#, Chen, X#., Luo, F#., Fujita, T., Ren, Z., Goldman, N., Zhao, Y., Nedergaard, M.; Traditional acupuncture triggers a local increase in adenosine in human subjects. Journal of Pain. 2012, 13(12): 1215-1223. (IF=4.92)

发表中文核心期刊(第一作者或通讯作者)

1.赵继宗邓晓峰陈晓霖神经外科在新型冠状病毒肺炎疫情常态化防控下的诊疗模式;中华医学杂志2020,100(47):3741-3743

2.马力、陈玉、陈晓霖;新型冠状病毒肺炎流行期间颅内破裂动脉瘤急诊手术诊疗流程及疗效评价;中华医学杂志2020,100(47):3768-3774

3.Chen, Y., X. Meng, L. Ma, Y. Zhao, Y. Gu, H. Jin, D. Gao, Y. Li, S. Sun, A. Liu, Y. Zhao, X. Chen*and S. Wang. "Contemporary Management of Brain Arteriovenous Malformations in Mainland China: A Web-Based Nationwide Questionnaire Survey." Chin Neurosurg J 6 (2020): 26

4.Chen, Y#., X. Chen#, L. Ma, X. Deng, Z. Li, X. Ye, H. Wang, S. Kang, Y. Zhang, R. Wang, D. Zhang, Y. Cao, Y. Zhao, S. Wang, and J. Zhao. "Management Protocol for Emergency Aneurysm Craniotomy Clipping in Non-Major Covid-19 Epidemic Areas in Beijing, China." Chin Neurosurg J 6, no. 1 (Dec 22 2020): 38.

5.Li, Z., L. Ma, C. Wu, J. Ma, and X. Chen. "Pediatric Brain Arteriovenous Malformation Unfavorable Hemorrhage Risk: Extrapolation to a Morphologic Model." Chin Neurosurg J 4 (2018): 15.

参与发表SCI文章

1.Lu, J., M. Li, J. K. Burkhardt, Y. Zhao, Y. Li, X. Chen, Y. Zhao, and J. Zhao. "Unruptured Giant Intracranial Aneurysms: Risk Factors for Mortality and Long-Term Outcome." Transl Stroke Res  (Nov 9 2020)

2.Chen, Y., R. Li, L. Ma, X. Meng, D. Yan, H. Wang, X. Ye, et al. "Long-Term Outcomes of Brainstem Arteriovenous Malformations after Different Management Modalities: A Single-Centre Experience." Stroke Vasc Neurol  (Sep 14 2020).

3.Ye, X., L. Wang, M. T. Li, X. L. Chen, H. Wang, L. Ma, R. Wang, et al. "Hemodynamic Changes in Superficial Arteriovenous Malformation Surgery Measured by Intraoperative Icg Fluorescence Videoangiography with Flow 800 Software." Chin Neurosurg J 6 (2020): 29.

4.Ye, X., P. C. Ge, L. Ma, Y. Chen, R. Duan, C. X. Tan, X. L. Chen, et al. "[the Application of Amodified Scalp Retractor in the Craniotomy for Intracranial Aneurysms]." Zhonghua Yi Xue Za Zhi 100, no. 31 (Aug 18 2020): 2467-69.

5.Lu, J., Z. Li, Y. Zhao, X. Chen, G. Shi, and J. Zhao. "Hemorrhagic Transformation in Ischemic Moyamoya Disease: Clinical Characteristics, Radiological Features, and Outcomes." Front Neurol 11 (2020): 517.

6.Guo, G., J. Liu, Y. Ren, X. Mao, Y. Hao, C. Zhong, X. Chen, et al. "Frat1 Enhances the Proliferation and Tumorigenesis of Cd133(+)Nestin(+) Glioma Stem Cells in Vitro and in Vivo." J Cancer 11, no. 9 (2020): 2421-30

7.Liang, J., X. Lv, C. Lu, X. Ye, X. Chen, J. Fu, C. Luo, and Y. Zhao. "Prognostic Factors of Patients with Gliomas - an Analysis on 335 Patients with Glioblastoma and Other Forms of Gliomas." BMC Cancer 20, no. 1 (Jan 15 2020): 35.

8.Zhao, Y., W. T. Jin, Y. K. Zhang, X. L. Chen, Y. L. Zhao, R. Wang, W. C. Zhang, X. Ye, and C. Zeng. "[Application of Combined Angiography in Diagnosis and Treatment of Carotid Artery Stenosis]." Zhonghua Yi Xue Za Zhi 99, no. 39 (Oct 22 2019): 3081-84.

9.Zhang, Y. K., Y. Zhao, W. T. Jin, X. Ye, X. L. Chen, W. C. Zhang, C. Zeng, Y. L. Zhao, and R. Wang. "[Simultaneous Treatments in Patients with Severe Carotid Artery Stenosis and Coronary Artery Disease]." Zhonghua Yi Xue Za Zhi 99, no. 39 (Oct 22 2019): 3077-80

10.Chen, Y., L. Ma, J. Lu, X. Chen, X. Ye, D. Zhang, Y. Zhang, R. Wang, and Y. Zhao. "Postoperative Hemorrhage During the Acute Phase after Direct or Combined Revascularization for Moyamoya Disease: Risk Factors, Prognosis, and Literature Review." J Neurosurg  (Oct 18 2019): 1-10

11.Lu, J., Y. Zhao, L. Ma, Y. Chen, M. Li, X. Chen, X. Ye, R. Wang, and Y. Zhao. "Predictors and Clinical Features of Transient Neurological Events after Combined Bypass Revascularization for Moyamoya Disease." Clin Neurol Neurosurg 186 (Nov 2019): 105505

12.Tan, C., H. Niu, R. Duan, G. Shi, Y. Zhao, X. Chen, X. Ye, and R. Wang. "Abnormal Embryonic Development of Cerebral Arteries as a Potential Cause of Moyamoya Disease." World Neurosurg 129 (Sep 2019): e224-e32.

13.Lu, J., Y. Zhao, L. Ma, Y. Chen, M. Li, X. Ye, R. Wang, X. Chen, and Y. Zhao. "Multimodal Neuronavigation-Guided Precision Bypass in Adult Ischaemic Patients with Moyamoya Disease: Study Protocol for a Randomised Controlled Trial." BMJ Open 9, no. 3 (Mar 20 2019): e025566

14.Li, Z., J. Lu, L. Ma, C. Wu, Z. Xu, X. Chen, X. Ye, R. Wang, and Y. Zhao. "Dl-3-N-Butylphthalide for Alleviation of Neurological Deficit after Combined Extracranial-Intracranial Revascularization for Moyamoya Disease: A Propensity Score-Matched Analysis." J Neurosurg 132, no. 2 (Feb 15 2019): 421-33.

15.Hao, Q., H. Wang, J. L. Lu, L. Ma, X. L. Chen, X. Ye, Y. H. Zhao, et al. "Activin Receptor-Like Kinase 1 Combined with Vegf-a Affects Migration and Proliferation of Endothelial Cells from Sporadic Human Cerebral Avms." Front Cell Neurosci 12 (2018): 525.

16.Lu, C. Y., X. L. Chen, X. L. Chen, X. J. Fang, and Y. L. Zhao. "Clinical Application of 3.0 T Intraoperative Magnetic Resonance Combined with Multimodal Neuronavigation in Resection of Cerebral Eloquent Area Glioma." Medicine (Baltimore) 97, no. 34 (Aug 2018): e11702.

17.Wu, C. X., L. Ma, X. Z. Chen, X. L. Chen, Y. Chen, Y. L. Zhao, C. Hess, et al. "Evaluation of Angioarchitectural Features of Unruptured Brain Arteriovenous Malformation by Susceptibility Weighted Imaging." World Neurosurg 116 (Aug 2018): e1015-e22.

18.Hao, Q., X. L. Chen, L. Ma, T. T. Wang, Y. Hu, and Y. L. Zhao. "Procedure for the Isolation of Endothelial Cells from Human Cerebral Arteriovenous Malformation (Cavm) Tissues." Front Cell Neurosci 12 (2018): 30.

19.Hao, Q., X. L. Chen, L. Ma, X. Ye, H. Wang, T. T. Wang, Y. Hu, and Y. L. Zhao. "In Vitro Characteristics of Endothelial Cells Prepared from Human Cerebral Arteriovenous Malformation Lesions Using a Novel Method." Microvasc Res 116 (Mar 2018): 57-63.

20.Ma, L., H. Kim, X. L. Chen, C. X. Wu, J. Ma, H. Su, and Y. Zhao. "Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation." Cerebrovasc Dis 43, no. 5-6 (2017): 231-41.

21.Lin, Z., M. Zhao, X. Ren, J. Wang, Z. Li, X. Chen, Y. Wang, et al. "Clinical Features, Radiologic Findings, and Surgical Outcomes of 65 Intracranial Psammomatous Meningiomas." World Neurosurg 100 (Apr 2017): 395-406

22.Lin, Z., Y. Wang, M. Zhao, Z. Li, X. Chen, and Z. Jiang. "Unusual Presentation of an Intracranial Hemangiopericytoma as a Cystic Intraparenchymal Mass Lesion Closely Mimicking a Glioma." Neurol India 65, no. 1 (Jan-Feb 2017): 208-09

23.Ma, L., X. L. Chen, Y. Chen, C. X. Wu, J. Ma, and Y. L. Zhao. "Subsequent Haemorrhage in Children with Untreated Brain Arteriovenous Malformation: Higher Risk with Unbalanced Inflow and Outflow Angioarchitecture." Eur Radiol 27, no. 7 (Jul 2017): 2868-76.

24.Wang, Y., Z. Lin, Z. Li, M. Zhao, M. Hu, H. Zhang, X. Chen, and Z. Jiang. "The Incidence and Risk Factors of Postoperative Entrapped Temporal Horn in Trigone Meningiomas." World Neurosurg 90 (Jun 2016): 511-17

25.Ma, L., X. L. Chen, J. Ma, and Y. L. Zhao. "The Associated Venous Anomalies Variant and Adjacent Brain Function on Iron Sensitive Image Indicate Surgical Risk of Cavernous Malformation." Neurol Med Chir (Tokyo) 56, no. 1 (2016): 9-20.

26.Ma, L., Z. Huang, X. L. Chen, J. Ma, X. J. Liu, H. Wang, X. Ye, et al. "Periventricular Location as a Risk Factor for Hemorrhage and Severe Clinical Presentation in Pediatric Patients with Untreated Brain Arteriovenous Malformations." AJNR Am J Neuroradiol 36, no. 8 (Aug 2015): 1550-7

27.Ma, J., Z. Zhang, S. Li, X. Chen, and S. Wang. "Intracranial Amelanotic Melanoma: A Case Report with Literature Review." World J Surg Oncol 13 (May 12 2015): 182.

28.Zhang, Z., H. Jiang, X. Chen, J. Bai, Y. Cui, X. Ren, X. Chen, et al. "Identifying the Survival Subtypes of Glioblastoma by Quantitative Volumetric Analysis of Mri." J Neurooncol 119, no. 1 (Aug 2014)

29.Li, T., J. Zhang, R. Y. Liu, Z. G. Lian, X. L. Chen, L. Ma, H. M. Sun, and Y. L. Zhao. "The Role of the Sonic Hedgehog Signaling Pathway in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats." Neurosci Lett 552 (Sep 27 2013): 81-6.

30.Liu, L., X. L. Chen, J. K. Yang, Z. G. Ren, and S. Wang. "Gliosis after Traumatic Brain Injury in Conditional Ephrinb2-Knockout Mice." Chin Med J (Engl) 125, no. 21 (Nov 2012): 3831-5.


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